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Most subjects were non-smokers (86%)

Some patients may experience alternating constipation and diarrhea, which could create a cycle of irritation and pressure changes in the anorectal region

Animal studies have suggested that GLP-1s act on the mesolimbic reward pathways and reduce drug reinforcement in alcohol, nicotine, cocaine, and opioid use disorders

Advances in understanding OSA pathophysiology have supported the development of targeted therapies that extend beyond mechanical airway support

It is of interest to note that FLNA splice variant-1, that was found widely expressed at low levels, lacks 41 amino acids between repeats 19 and 20, the region involved in the interaction both with DRD2 and SST2